The CanRisk Web Tool incorporates the new version of BOADICEA,
the Breast and Ovarian
Analysis of Disease Incidence
and Carrier Estimation Algorithm.
BOADICEA is a comprehensive model that can be used to calculate the future risks of developing breast
or ovarian cancer using information on family history, lifestyle/hormonal risk factors,
rare pathogenic variants in moderate and high risk breast/ovarian cancer susceptibility genes,
common breast/ovarian cancer genetic susceptibility variants (Polygenic Risk Scores) and
mammographic density. It can also be used to calculate the likelihood of carrying mutations
in the moderate to high risk genes BRCA1, BRCA2, PALB2, ATM and CHEK2.