The CanRisk tool is a web interface to BOADICEA, the Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm, risk prediction model used to calculate future breast and ovarian cancer risks in women. This is the first comprehensive model that allows for reliable breast and ovarian cancer risk prediction in unaffected women on the basis of mutation screening information for rare (high risk and moderate risk) breast and ovarian cancer genetic susceptibility variants, common cancer genetic susceptibility variants (using polygenic risk scores), explicit family history, personal lifestyle, hormonal and reproductive risk factors, and mammographic density in the case of breast cancer. The breast and ovarian cancer models are described in Lee et al. 2019, Lee et al 2021 and Lee et al 2022.
For details see 'What information do the breast and ovarian cancer models use to determine risks?'
This work is supported by grants through Cancer Research UK, the European Union’s Horizon 2020 and Innovation programme, Genome Canada and a Wellcome Trust Collaborative Award.
Please see more details here on the Cancer Research-UK funded CanRisk programme.
The CanRisk Tool carries the CE marking and has been created and maintained by the University of Cambridge.
If you use the CanRisk tool or web-services then we ask that you cite Lee et al. (Genet Med, 2019), Carver et al. (Cancer Epidemiol Biomarkers Prev, 2020) and Archer et al. (PLoS One 2020) in any resulting work or publications. We would be grateful if you could please also acknowledge the funding that supports the running of CanRisk by including the following acknowledgement: The CanRisk tool is supported by grant PPRPGM-Nov20\100002 from Cancer Research UK.
If you use the CanRisk web-services in a third party application then we ask that you acknowledge this on the application and link to the CanRisk home page (canrisk.org). To allow us to manage resources, we also ask that you inform us of expected usage (number of calculations) and the user account that calculations will be run from.